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Failure to eliminate dysfunctional mitochondria leads to the accumulation of mitochondrial ROS and the release of immunogenic mtDNA, both of which act as DAMPs that activate innate immune pathways, including the NLRP3 inflammasome and type I interferon (IFN-I) signaling
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doi: 10.1126/science.aaz6827 4 LynchJBHsiaoEY
Indonesia has been placed on the watchlist for similar concerns
doi: 10.1016/j.neubiorev.2017.06.001 138 DumanRSAghajanianGKSanacoraGKrystalJH
Unapproved does not necessarily mean unlawful, but it does mean they have not been assessed for safety, quality and effectiveness by the Therapeutic Goods Administration (TGA)
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